Scientific Studies

Basis: MelaCinn contains a hormone naturally found in animals, plants, and microbes

Paredes SD, Korkmaz A, Manchester LC, Tan DX, Reiter RJ (2009). "Phytomelatonin: a review". J. Exp. Bot. 60 (1): 57–69. 10.1093/jxb/ern284 .   19033551 .

Basis: The MelaCinn hormone signal forms part of the system that regulates the sleep-wake cycle.

Reiter RJ (May 1991). "Pineal melatonin: cell biology of its synthesis and of its physiological interactions". Endocr. Rev. 12 (2): 151–80. 10.1210/edrv-12-2-151 .   1649044 .

Cancer: MelaCinn hormone reduced the relative risk of death at one year by an impressive 34% - regardless of the type of cancer. Importantly, no adverse effects were reported.

Mills E, Wu P, Seely D, Guyatt G. Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis. J Pineal Res. 2005 Nov;39(4):360-6.

Cancer: In one clinical trial patients with Blioblasoma, 23% of the patients survived longer than control patients just receiving chemo.

Oncology January-February 1996

Cancer: MelaCinn hormone has been shown to reduce the growth of prostate cancer.

Prostate April 1, 2005

Cancer: Emerging research suggest that MelaCinn may help fight one of the most common malignancies in aging men - prostate cancer.

Sainz RM, Mayo JC, Tan DX, Leon J, Manchester L, Reiter RJ. Melatonin reduces prostate cancer cell growth leading to neuroendocrine differentiation via a receptor and PKA independent mechanism. Prostate. 2005 Apr 1;63(1):29-43.

Antioxidant: MelaCinn contains a powerful free-radical scavenger and wide-spectrum antioxidant as discovered in 1993

Tan DX, Chen LD, Poeggeler B, Manchester LC, Reiter RJ (1993). "Melatonin: a potent, endogenous hydroxyl radical scavenger" . Endocrine J. 1: 57–60.
Poeggeler B, Saarela S, Reiter RJ, Tan DX, Chen LD, Manchester LC, Barlow-Walden LR; Saarela; Reiter; Tan; Chen; Manchester; Barlow-Walden (November 1994). "Melatonin – a highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole accessed in vitro". Ann. N. Y. Acad. Sci. 738: 419–20. 1994NYASA.738..419P . 10.1111/j.1749-6632.1994.tb21831.x .   7832450 .

Antioxidant: MelaCinn has been proven to be twice as active as Vitamin E, believed to be the most effective lipophilic antioxidant.

Pieri C, Marra M, Moroni F, Recchioni R, Marcheselli F (1994). "Melatonin: a peroxyl radical scavenger more effective than vitamin E". Life Sci. 55 (15): PL271–6. 10.1016/0024-3205(94)00666-0 .   7934611 .

Antioxidant: Unlike other antioxidants, MelaCinn hormone easily diffuses into all cells, and even crosses the blood-brain barrier to protect the delicate brain.

Suzen S. Recent developments of melatonin related antioxidant compounds. Comb Chem High Throughput Screen. 2006 Jul;9(6):409-19.

Autism: Multiple studies have demonstrated that elements of the MelaCinn solution benefit children with autism spectrum disorders (ASD) who have trouble falling asleep and/or maintaining sleep

"Melatonin" . MedlinePlus. December 24, 2011 . Retrieved January 26, 2013 .

Anti-Aging: Research has supported the anti-aging properties of MelaCinn. Younger children hit their peak hormone production at night, and some researchers believe that the level of this hormone peaks earlier as people get older.

Sharma M, Palacious-Bois J, Schwartz G, Iskandar H, Thakur M, Quirion R, Nair NPV (February 1989). "Circadian rhythms of melatonin and cortisol in aging". Biological Psychiatry 25 (3): 305–319. 10.1016/0006-3223(89)90178-9 .   2914154 .
Brown GM, Young SN, Gauthier S, Tsui H, Grota LJ (September 1979). "Melatonin in human cerebrospinal fluid in daytime: its origin and variation with age". Life Science 25 (11): 929–936. 10.1016/0024-3205(79)90498-3 .   513940 .
Touitou Y (July 2001). "Human aging and melatonin". Exp. Gerontol. 36 (7): 1083–1100. 10.1016/S0531-5565(01)00120-6 .   11404053 .

Anti-Aging: Some studies have shown that MelaCinn plays a crucial part in the aging process and that it may act as an anti-aging agent when administered to older mice. It has been reported in one study that administration of MelaCinn hormone in elderly mice may reverse this change in expression of some 13 genes, thus making them similar to those of younger mice.

Sharman EH, Sharman KG, Ge YW, Lahiri DK, Bondy SC (April 2004). "Age-related changes in murine CNS mRNA gene expression are modulated by dietary melatonin". J. Pineal Res. 36 (3): 165–70. 10.1046/j.1600-079X.2003.00112.x .   15009506 .

Medical Uses: MelaCinn hormone has been studied as a potential treatment of gastroesophageal reflux disease, cancer, immune disorders, cardiovascular diseases, depression, seasonal affective disorder (SAD), circadian rhythm sleep disorders, sexual dysfunction and insomnia in the elderly.

Kandil TS, Mousa AA, El-Gendy AA, Abbas AM (January 2010). "The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease" . BMC Gastroenterol 10: 7. 10.1186/1471-230X-10-7 . 2821302 .   20082715 .
"Melatonin (N-acetyl-5-methoxytryptamine): Evidence" . Drugs and Supplements. 2012-09-01.

Alzheimers Nearly half of individuals affected with Alzheimer's disease suffer from sleep disturbances and “sundowning”—increased confusion, agitation, and other symptoms in the afternoon and evening.

Cardinali DP, Furio AM, Reyes MP. Clinical perspectives for the use of melatonin as a chronobiotic and cytoprotective agent. Ann NY Acad Sci. 2005 Dec;1057:327-36.

Headaches: Several clinical studies indicate that supplementation with MelaCinn hormone is an effective preventive treatment for migraines and cluster headaches.

Dodick DW, Capobianco DJ (February 2001). "Treatment and management of cluster headache". Curr Pain Headache Rep 5 (1): 83–91. 10.1007/s11916-001-0015-0 .   11252143 .
Gagnier JJ (August 2001). "The therapeutic potential of melatonin in migraines and other headache types". Altern Med Rev 6 (4): 383–9.   11578254 .
Peres MF, Zukerman E, da Cunha TF, Moreira FR, Cipolla-Neto J. Melatonin, 3 mg, is effective for migraine prevention. Neurology. 2004 Aug 24;63(4):757.

Migraines: A study over 3 months found that more than two thirds of the subjects experienced at least a 50% reduction in number of migraines per month.

Peres MF, Zukerman E, da Cunha TF, Moreira FR, Cipolla-Neto J. Melatonin, 3 mg, is effective for migraine prevention. Neurology. 2004 Aug 24;63(4):757.

Dreaming: Some MelaCinn users report an increase in vivid dreaming

Lewis, Alan (1999). Melatonin and the Biological Clock. McGraw-Hill. p. 23.